Oncogenes induce a reversal of replication’s fortunes

Oncogenes induce a reversal of replication’s fortunes

Oncogenes induce a reversal of replication’s for tunes N eelsen et al. describe how certain oncogenes can perturb DNA replication and induce DNA damage. Several oncogenes, including Cyclin E and Cdc25A, push cells precipitously into S phase, resulting in numerous DNA double-strand breaks (DSBs). But how S phase deregulation disrupts replication and induces DNA damage is unclear. To fi nd out, N...

Reversal in the Fortunes of the Plains

Reversal of fortunes: recognizing misplacement of ECG electrodes.

PRESENTATION Electrocardiography is the most commonly performed cardiovascular procedure. Careful inspection of the electrocardiogram (ECG) is essential for accurate identification of abnormalities. Two cases illustrate how a simple procedural error can potentially alter the diagnosis and management of patients presenting with acute cardiovascular emergencies. A 73-year-old woman with a history...

Human-induced reversal of fortunes for migratory ungulates?

Animal migrations link different ecosystems, with important consequences for nutrient cycling, trophic webs, and disease transmission over very large scales. Migratory populations usually reach much greater numbers than nonmigratory populations of the same or similar species, and many have substantial economic impacts. Many migratory populations of birds, fishes, reptiles, insects, and mammals ...

A reversal of fortunes: climate change ‘winners’ and ‘losers’ in Antarctic Peninsula penguins

Climate change is a major threat to global biodiversity. Antarctic ecosystems are no exception. Investigating past species responses to climatic events can distinguish natural from anthropogenic impacts. Climate change produces 'winners', species that benefit from these events and 'losers', species that decline or become extinct. Using molecular techniques, we assess the demographic history and...